The point about randomization is key, BTW, because the theoretical training effect is actually greater than the observed improvement between randomized days. Watch: I noticed what may have been an effect on my dual n-back scores; the difference is not large (▃▆▃▃▂▂▂▂▄▅▂▄▂▃▅▃▄ vs ▃▄▂▂▃▅▂▂▄▁▄▃▅▂▃▂▄▂▁▇▃▂▂▄▄▃▃▂▃▂▂▂▃▄▄▃▆▄▄▂▃▄▃▁▂▂▂▃▂▄▂▁▁▂▄▁▃▂▄) and appears mostly in the averages - Toomim’s quick two-sample t-test gave p=0.23, although a another analysis gives p=0.138113. One issue with this before-after quasi-experiment is that one would expect my scores to slowly rise over time and hence a fish oil after would yield a score increase - the 3.2 point difference could be attributable to that, placebo effect, or random variation etc. But an accidentally noticed effect (d=0.28) is a promising start. An experiment may be worth doing given that fish oil does cost a fair bit each year: randomized blocks permitting an fish-oil-then-placebo comparison would take care of the first issue, and then blinding (olive oil capsules versus fish oil capsules?) would take care of the placebo worry. Power Athletes Bundle ← Frequently Asked Questions npt <- read.csv("https://www.gwern.net/docs/nootropics/2013-gwern-noopept.csv") Enhances mental drive and acuity What Are Nootropics? A Guide to Nootropic Supplements "Fructo-oligosaccharides (also known as FOS)—this supplement is going to really surprise you, because it is not a brain-specific supplement. It’s actually a fermentable dietary fiber that acts as a prebiotic in the gut. Why is this important? Well, you may know about the gut-brain connection, but did you know that a metabolic by-product from your gut flora, butyrate, acts as a histone deacetylase (HDAC) inhibitor? Say what? HDAC is an enzyme that controls the rate of gene expression, by inhibiting it, butyrate promotes cellular protective mechanisms, including the secretion of brain-derived neurotrophic factor (BDNF), a very important signal to increase the number of neural connections, facilitating learning, short-term and long-term memory. Back to FOS, it feeds a group of bacteria that ferment it into butyrate, this key anti-inflammatory short-chain fatty acid, that enters the circulation, crosses the blood-brain barrier easily, then affects gene expression in the brain. The lesson: you need a happy gut (microbiome) to have a healthy brain."

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