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In 2015, systematic medical reviews and meta-analyses of clinical research in humans established consensus that certain central nervous system stimulants, only when used at low (therapeutic) concentrations, unambiguously enhance cognition in the general population; in particular, the classes of stimulants that demonstrate cognition-enhancing effects in humans act as direct agonists or indirect agonists of dopamine receptor D1, adrenoceptor A2, or both receptors in the prefrontal cortex. Relatively high doses of stimulants cause cognitive deficits.
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-funny message the moderators It’s not clear that there is much of an effect at all. This makes it hard to design a self-experiment - how big an effect on, say, dual n-back should I be expecting? Do I need an arduous long trial or an easy short one? This would principally determine the value of information too; chocolate seems like a net benefit even if it does not affect the mind, but it’s also fairly costly, especially if one likes (as I do) dark chocolate. Given the mixed research, I don’t think cocoa powder is worth investigating further as a nootropic.
Safety issues We can double-check this by seeing what the variance is for the unaveraged scores: we know the means are only 1.1% different, so the additional standard deviation must be coming from how individual days are good or bad, and if that is so, then unaveraging them out to eliminate most of the observed difference. We re-run BEST:
# as.integer(Date) 0.0003 0.0011 NA 0.4930 0.4897
Benton D1, Donohoe RT, Sillance B, Nabb S. The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor. Nutr Neurosci. 2001;4(3):169-78.
6 - 8 October: 0 Vitality Read all reviews # 0.856387 • Helps achieve optimal relaxation # as.logical(Magnesium.citrate)TRUE:as.integer(Date) -0.001699162 0.001222719 -1.38966 0.16625033
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lithiumExperiment <- read.csv("https://www.gwern.net/docs/lithium/2012-lithium-experiment.csv")
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NATURE’S ADEROL? DMAE 100 mg Thyroid Health 48mg: 24 - 26 May: 1 In retrospect, there were 2 parts of the experiment design I probably should have changed:
Data Health Tech patchLines <- as.list(patchLines) Opinion # Multiple R-squared: 0.065, Adjusted R-squared: 0.0605
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Some think that brain-healthy diets are just a fad, with no scientific backing behind them, [...] as.logical(Magnesium.citrate) + as.integer(Date) + as.logical(Magnesium.citrate):as.integer(Date),
Immune Support # Response MR4 : A new study from Japan shows that taking daily supplements containing L-Theanine may also help people with anxiety focus on their daily activities.
BDNF plays a crucial role in the growth, differentiation and maintenance of neurons in general, while NGF is vital for the survival of sympathetic and sensory neurons.
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Kids (4) Just like fitness enthusiasts try to lower their risk of diseases by exercising regularly and eating healthy, we should closely monitor our mental health. One common problem is that many people wait too long before seeking help which decreases* success rate for treatment.
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