11 AM; a rather productive day. I give it 65%. To my surprise, it was placebo.
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Fortunately, several systematic reviews and meta-analyses on the use of nootropics were published in the last couple of years. Systematic reviews and meta-analyses combine data from multiple individual studies, thus making conclusions more statistically reliable. This is a better way of assessing the efficacy of different drugs in the general, healthy population, and these are the publications that I will mostly use as reference points in this article.
" BY RUSSELL LEE Clinical studies are lacking but users and researchers have discussions on their experiences with the medication: [R, R, R, R, R]. Thursday: 3g piracetam/4g choline bitartrate at 1; 1 200mg modafinil at 2:20; noticed a leveling of fatigue by 3:30; dry eyes? no bad after taste or anything. a little light-headed by 4:30, but mentally clear and focused. wonder if light-headedness is due simply to missing lunch and not modafinil. 5:43: noticed my foot jiggling - doesn’t usually jiggle while in piracetam/choline. 7:30: starting feeling a bit jittery & manic - not much or to a problematic level but definitely noticeable; but then, that often happens when I miss lunch & dinner. 12:30: bedtime. Can’t sleep even with 3mg of melatonin! Subjectively, I toss & turn (in part thanks to my cat) until 4:30, when I really wake up. I hang around bed for another hour & then give up & get up. After a shower, I feel fairly normal, strangely, though not as good as if I had truly slept 8 hours. The lesson here is to pay attention to wikipedia when it says the half-life is 12-15 hours! About 6AM I take 200mg; all the way up to 2pm I feel increasingly less energetic and unfocused, though when I do apply myself I think as well as ever. Not fixed by food or tea or piracetam/choline. I want to be up until midnight, so I take half a pill of 100mg and chew it (since I’m not planning on staying up all night and I want it to work relatively soon). From 4-12PM, I notice that today as well my heart rate is elevated; I measure it a few times and it seems to average to ~70BPM, which is higher than normal, but not high enough to concern me. I stay up to midnight fine, take 3mg of melatonin at 12:30, and have no trouble sleeping; I think I fall asleep around 1. Alarm goes off at 6, I get up at 7:15 and take the other 100mg. Only 100mg/half-a-pill because I don’t want to leave the half laying around in the open, and I’m curious whether 100mg + ~5 hours of sleep will be enough after the last 2 days. Maybe next weekend I’ll just go without sleep entirely to see what my limits are.
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Personal Experience: SmartX seems more commercial than underground which was initially a turn off. However, I felt the effects of SmartX stronger than all others. I had strong, locked in focus for 4-5 hours. I was also able to multi task and bounce between ideas without losing my train of thought.
In order to boost your cognition you need to ensure you are getting enough of certain nutrients.
# LLLTTRUE 0.2556655 0.1299869 1.96686 0.050045 The importance and function of Uridine are known within the body, but the effect of supplements is still unidentified. Some of the key ingredients include Phosphatidylserine, Huperzine A, Schisandrin A, and Vinpocetine. This is a highly effective combination of ingredients that has been tested by hundreds of consumers who only had positive things to say about it.
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On the other metric, suppose we removed the creatine? Dropping 4 grams of material means we only need to consume 5.75 grams a day, covered by 8 pills (compared to 13 pills). We save 5,000 pills, which would have cost $45 and also don’t spend the $68 for the creatine; assuming a modafinil formulation, that drops our $1761 down to $1648 or $1.65 a day. Or we could remove both the creatine and modafinil, for a grand total of $848 or $0.85 a day, which is pretty reasonable.
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World news ^ Linssen AM, Sambeth A, Vuurman EF, Riedel WJ (June 2014). "Cognitive effects of methylphenidate in healthy volunteers: a review of single dose studies". Int. J. Neuropsychopharmacol. 17 (6): 961–977. doi:10.1017/S1461145713001594. PMID 24423151. The studies reviewed here show that single doses of MPH improve cognitive performance in the healthy population in the domains of working memory (65% of included studies) and speed of processing (48%), and to a lesser extent may also improve verbal learning and memory (31%), attention and vigilance (29%) and reasoning and problem solving (18%), but does not have an effect on visual learning and memory. MPH effects are dose-dependent and the dose-response relationship differs between cognitive domains.
In the United States dietary supplements may be marketed if the manufacturer can show that it can manufacture the supplement safely, that the supplement is indeed generally recognized as safe, and if the manufacturer does not make any claims about the supplement's use to treat or prevent any disease or condition; supplements that contain drugs or for which treatment or prevention claims are made are illegal under US law.
10 sciencedirect.com/scienc... Darbinyan V, Aslanyan G, Amroyan E, Gabrielyan E, Malstrom C, Panossian A. Clinical trial of Rhodiola rosea extract SHR-5 in the treatment of mild to moderate depression.Nord J Psychiatry. 2007; 61(5):343-348.
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#  0.0701653002 It is possible also possible to combine different nootropics, known as “stacking,” resulting in a powerful synergistic effect where the individual components of the stack produce an effect greater than the sum of their individual effects.
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The Queen Modafinil and Armodafinil are extremely potent and powerful “smart drugs.” They are not meant for everyone and probably pack the strongest physical and mental energy boost of any other brain supplement mentioned on this list.
So I began looking further into the data to see just what had happened (perhaps horrendous bad luck on a few days), and turned to a plot: 4.7 out of 5 stars 1,478
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Loading, please wait ... npt <- read.csv("https://www.gwern.net/docs/nootropics/2013-gwern-noopept.csv")
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Krissy Kendall, PhD $59.99 It’s recommended you avoid these synthetic nootropics unless you have a prescription, as they may cause more harm than good in the long-term. . Whole pill at 3 AM. I spend the entire morning and afternoon typing up a transcript of Earth in My Window. I tried taking a nap around 10 AM, but during the hour I was down, I had <5m of light sleep, the Zeo said. After I finished the transcript (~16,600 words with formatting), I was completely pooped and watched a bunch of Mobile Suit Gundam episodes, then I did Mnemosyne. The rest of the night was nothing to write home about either - some reading, movie watching, etc. Next time I will go back to split-doses and avoid typing up 110kB of text. On the positive side, this is the first trial I had available the average daily grade Mnemosyne 2.0 plugin. The daily averages all are 3-point-something (peaking at 3.89 and flooring at 3.59), so just graphing the past 2 weeks, the modafinil day, and recovery days: ▅█▅▆▄▆▄▃▅▄▁▄▄ ▁ ▂▄▄█. Not an impressive performance but there was a previous non-modafinil day just as bad, and I’m not too sure how important a metric this is; I must see whether future trials show similar underperformance. Nights: 11:29; 9:22; 8:25; 8:41.
Camfield DA et al. (2014) Acute effects of tea constituents L-theanine, caffeine, and epigallocatechin gallate on cognitive function and mood: a systematic review and meta-analysis. Nutr Rev 72, 507-522. DOI: https://doi.org/10.1111/nure.12120
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