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Brain tissue health is also dependent upon adequate perfusion of blood to sustain enough oxygen and nutrients. In fact loss of blood flow is connected to various neurological issues (such as dementia) (18).
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Increases insulin levels, which is linked to memory enhancement [R]. 5.0 out of 5 stars 8
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"Fructo-oligosaccharides (also known as FOS)—this supplement is going to really surprise you, because it is not a brain-specific supplement. It’s actually a fermentable dietary fiber that acts as a prebiotic in the gut. Why is this important? Well, you may know about the gut-brain connection, but did you know that a metabolic by-product from your gut flora, butyrate, acts as a histone deacetylase (HDAC) inhibitor? Say what? HDAC is an enzyme that controls the rate of gene expression, by inhibiting it, butyrate promotes cellular protective mechanisms, including the secretion of brain-derived neurotrophic factor (BDNF), a very important signal to increase the number of neural connections, facilitating learning, short-term and long-term memory. Back to FOS, it feeds a group of bacteria that ferment it into butyrate, this key anti-inflammatory short-chain fatty acid, that enters the circulation, crosses the blood-brain barrier easily, then affects gene expression in the brain. The lesson: you need a happy gut (microbiome) to have a healthy brain."
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# nuLog10 1.3484496 1.3548794 1.3570830 0.6442172 2.0117475 NA
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Maritime Pine Bark Extract is the best antioxidant nootropic because it combines potent brain anti-aging activity with natural support for brain blood flow and brain regeneration.
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Common synthetic nootropics include Piracetam, Aniracetam,Oxiracetam, Pramiracetam and Phenylpiracetam, which all come from the racetam family (meaning they all share a similar chemical structure). They’ve been studied for their broad range of applications, from improvements in general cognition and working memory to protection against the breakdown of neurons in the brain[*][*][*][*][*][*].
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Inside Mind & Mood: Flaxseed oil is, ounce for ounce, about as expensive as fish oil, and also must be refrigerated and goes bad within months anyway. Flax seeds on the other hand, do not go bad within months, and cost dollars per pound. Various resources I found online estimated that the ALA component of human-edible flaxseed to be around 20% So Amazon’s 6lbs for $14 is ~1.2lbs of ALA, compared to 16fl-oz of fish oil weighing ~1lb and costing ~$17, while also keeping better and being a calorically useful part of my diet. The flaxseeds can be ground in an ordinary food processor or coffee grinder. It’s not a hugely impressive cost-savings, but I think it’s worth trying when I run out of fish oil.
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The dopaminergic and serotonergic neurotransmitters are part of the central nervous system responsible for motivation, mood, reward and some aspects of memory and focus. Nootropic drugs will act on the nervous system by affecting certain dopamine and serotonin neurotransmitters and receptors. Such may improve the mood of users and other brain functions. On the flipside, nootropics that affect the dopaminergic and serotonergic system are quite addictive and it is advisable not to use them on a regular basis.
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Research finds that this combination up-regulates the gene SERPINI1, which gives the instructions to make a protein called neuroserpin. In the News
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In rats, injecting 300 μg/kg of Selank increased memory trace stability for one month [R]. eMedicineHealth
Contrarily, however to this, racetam drugs are known to facilitate enzyme activity to modulate changes in a key membrane receptor in the central nervous system: AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid). This particular receptor controls glutamate to increase transmission of impulses in our nervous systems, and as such if activated can boost the function of the brain’s synaptic activity.
On the other hand, sometimes you’ll feel a great cognitive boost as soon as you take a pill. That can be a good thing or a bad thing. I find, for example, that modafinil makes you more of what you already are. That means if you are already kind of a dick and you take modafinil, you might act like a really big dick and regret it. It certainly happened to me! I like to think that I’ve done enough hacking of my brain that I’ve gotten over that programming… and that when I use nootropics they help me help people.
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