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04 Increases growth hormone [R, R]. This analysis suggests that there’s a 95% probability the effect is somewhere between -0.129 & 0.208 (d=-0.22 - d=0.35), similar to the original linear model’s CI. More relevantly: there is only a 70% probability that the effect is >0 (albeit probably tiny), and >99.99% probability it’s not as big as the pilot data had claimed.
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Caffeine dose dependently decreased the 1,25(OH)(2)D(3) induced VDR expression and at concentrations of 1 and 10mM, VDR expression was decreased by about 50-70%, respectively. In addition, the 1,25(OH)(2)D(3) induced alkaline phosphatase activity was also reduced at similar doses thus affecting the osteoblastic function. The basal ALP activity was not affected with increasing doses of caffeine. Overall, our results suggest that caffeine affects 1,25(OH)(2)D(3) stimulated VDR protein expression and 1,25(OH)(2)D(3) mediated actions in human osteoblast cells.
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The interpretation which seems to best resolve everything I know about magnesium with the data from my experiment is that magnesium supplementation does indeed help me a large amount, but I was taking way too much.
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